The Guest Editor of this issue is a pediatric emergency medicine specialist and the Chief Medical Officer at Children’s Hospital of Pittsburgh. He is very involved in the medical record and other electronic devices as safety measures. He brings his expertise and breadth of knowledge to the Pediatric Clinics of North America to assemble a stand out list of authors who have contributed articles on Pediatric Safety, Quality & Informatics. In this issue, articles are devoted to Big Data and the role of Predictive Analytics in Pediatrics; Research in Pediatric IT- the present and the future; Quality Care and Patient Safety in the pediatric emergency department; Safety & Quality metrics for Pediatric Hospital Medicine; Clinical Effectiveness Guidelines- Easy to Create but Hard to Implement; Advanced Technology in the pediatric ICUs; Measurement, Standards and Peer Benchmarking in Pediatric Safety & Quality: One hospital’s journey; Clinical Informatics and its role in the care of children; Pediatric Safety & Quality: A nursing perspective; Pediatric Telehealth: opportunities and challenges; and Fundamentals of Quality Improvement: How to do pediatric QI research.