This issue of Medical Clinics of North America, Guest Edited by Deborah Wolbrette, MD is devoted to Cardiovascular Disease. Dr. Wolbrette has assembled a group of expert authors to review the following topics: Syncope due to Autonomic Dysfunction: Diagnosis and Management; 2013 Lipid Guidelines; 2014 Guideline for the Management of High Blood Pressure (JNC8); How to Follow Patients with Aortic and Mitral Valve Disease; The New Anticoagulants; Management of Atrial Fibrillation; Indications for Pacemakers, Implantable Defibrillators and Resynchronization Therapy; Current Status of Transcatheter Aortic Valve Replacement (TAVR); Chest Pain Evaluation: When to Order Troponin and Stress Tests/Cost Analysis; Indications for Cardiac MRI; Current Management of Heart Failure: When to Refer to Heart Failure Specialist and When is Hospice the Best Option; and Emerging Role of Digital Technology/Remote Monitoring in the Care of Cardiac Patients.