This issue of Immunology and Allergy Clinics provides the latest essential updates in food allergies. Topics include the following: mechanisms of allergic sensitization to foods—bypassing immune tolerance pathways; determinants of food allergenicity; epidemiology of food allergy; prevention of food allergy through manipulating the timing of food exposure; diagnosis and management of eosinophilic esophagitis; the burden of food allergies and mental health issues; state-of-the-art and new horizons in food allergy diagnostic testing; food-induced anaphylaxis; oral tolerance; immunotherapy for food allergy; complementary and alternative medicine for food allergy; paradigm shift in management of milk and egg allergy—baked milk and egg diet.