This multidisciplinary issue of Heart Failure Clinics examines a critical element in the management and treatment of heart failure (HF)—exercise and rehabilitation. Topics include the reversal of HF-associated pathophysiology with exercise; quantifying function; prognosis; rehabilitation practice patterns in the United States, Canada, South America, Asia, and Europe; special considerations such as obesity, high-intensity interval training, inspiratory muscle training, and technology to promote and increase physical activity.