That patients self-treat for such disorders as anxiety, depression, addictions, sleep disorders, attention deficit, is no surprise among psychiatrists. Hearing from patients, or parents of patients who use alternative therapies on themselves or their children, more scientifically-based facts are needed on non-pharmacologic, non–analysis approaches. The Guest Editors of this issue in Psychiatric Clinics have been using, researching, and analyzing alternative approaches since the 1990s and present a scientifically based presentation of select therapies, such as Nutrients, Herbals, Off-label Medication uses, Mind-Body approaches, Meditation, Hypnosis, Electrotherapy, Light treatments and more. Mechanisms of action, Outcomes, Evidence, and Complications are part of the outline for this material, with intent to provide the most current and the strongest science available.