Lactation: A Comprehensive Treatise, Volume II, Biosynthesis and Secretion of Milk/Diseases, is part of a three-volume treatise containing a total of 28 chapters. The present volume is devoted to the functioning of the mammary gland in the synthesis and secretion of milk. Emphasis has been placed on studies which have described on a biochemical and molecular basis the operation of the pathways and structures involved in the biosynthesis of milk in the functional secretory cells of the mammary gland and the diseases of lactation that can affect them. The volume is organized into two parts. Part I on the biosynthesis of milk covers topics such as the general metabolism associated with the synthesis of milk; biosynthesis of milk fat and milk proteins; biochemistry of lactose and related carbohydrates; and cell structure relating to the formation and secretion of milk. Part II on diseases of the mammary gland and lactation includes studies on the clinical endocrinology of prolactin, microbial diseases of the mammary gland, ketosis, and mouse mammary tumors.